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1 article(s) from Schütz, Christian

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

Christian Schütz and
Martin Empting

Beilstein J. Org. Chem. 2018, 14, 2627–2645, doi:10.3762/bjoc.14.241

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Graphical Abstract

Figure 1: The four quorum sensing systems in P. aeruginosa las, iqs, rhl, and pqs. Abbreviations: OdDHL, N-(3...

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Figure 2: Schematic overview of the PQS biosynthesis and involvement of related metabolites and PqsE in virul...

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Figure 3: Anthranilic acid (1) and derivatives thereof (2–4).

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Figure 4: Crystal structure of 6-FABA-AMP in complex with PqsA.

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Figure 5: Structures of substrate mimetic PqsA inhibitors.

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Figure 6: Structures and characteristics of prominent classes of PqsD inhibitors.

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Figure 7: Comparison of docking poses of three prototypic PqsD inhibitors: benzamidobenzoic acid derivative 12...

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Figure 8: Structures and characteristics of hits against PqsD identified through different methods.

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Figure 9: HHQ and PQS analogues as PqsD inhibitors and chemical probe used for screening.

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Figure 10: Structure of PqsD-targeting biofilm inhibitor derived from linezolid.

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Figure 11: Fragment-based PqsE-inhibitors 24–26.

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Figure 12: PqsE co-crystal structures. (A) native product 2-ABA; (B–D) hit fragments 24–26.

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Figure 13: Structurally diverse PqsBC-inhibitors 27–30.

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Figure 14: Native PqsR ligand HHQ (31) which is converted into PQS (32) by PqsH and synthetic inhibitors 33 an...

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Figure 15: Quinazolinone inhibitor 36 (QZN).

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Figure 16: Crystal structure of QZN (36) in complex with PqsR^CBD.

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Figure 17: Structures of best fitting compounds 37–40 obtained from docking studies.

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Figure 18: Initial hit 21 and optimized compound 42 (M64).

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Figure 19: Co-crystal structure of M64 (42) with PqsR^LBD.

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Figure 20: M64 (42) as the starting point for further optimization leading to 43, which was further modified a...

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Figure 21: Hit fragments from the benzamide (47–48) and oxadiazole class (49–51).

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Figure 22: Structures of dual inhibitors 52–55.

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Figure 23: Sulfonyl pyrimidines 56–58 acting as dual PqsD/PqsR inhibitors.

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Album

Review

Published 15 Oct 2018

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